The bright main concourse at McGhee Tyson Airport (TYS), with river-rock water features and plantings along the walkway

Airlines at McGhee Tyson · network explorer

Six airlines fly from Knoxville. Pick one.

Allegiant, American, Avelo, Delta, Southwest and United. Choose an airline and the map and list filter to its Knoxville network, with the hubs it opens up beyond.

Photo: Jackmcafee, CC BY-SA 3.0 / Wikimedia Commons

Short answer

Six airlines fly nonstop from Knoxville (TYS): Allegiant (21), Southwest (7), American (6), United (5), Delta (4), Avelo (1). Numbers are destinations as of October 19, 2026. Frontier left in August 2026.

Explorer

The network, airline by airline.

Tap an airline. Seasonal and announced routes are dashed.

Knoxville airline network36 of 36 shown

AllegiantAmericanAveloDeltaSouthwestUnitedSeasonal or announced (dashed)

Atlanta ATL Delta
Austin AUS Allegiant, Southwest · seasonal
Baltimore/Washington BWI Southwest
Boston BOS Allegiant · seasonal
Charlotte CLT American
Chicago (Midway) MDW Allegiant · seasonal
Chicago (O'Hare) ORD American, United
Dallas (Love Field) DAL Southwest
Dallas/Fort Worth DFW American
Denver DEN United, Allegiant, Southwest
Destin/Fort Walton Beach VPS Allegiant
Detroit DTW Delta
Fort Lauderdale FLL Allegiant
Gulf Shores/Orange Beach GUF Allegiant · seasonal
Houston (Hobby) HOU Allegiant · seasonal
Houston (Intercontinental) IAH United
Jacksonville JAX Allegiant
Key West EYW Allegiant · seasonal
Las Vegas LAS Allegiant, Southwest (announced)
Memphis MEM Allegiant · seasonal
Miami MIA American
Minneapolis-St. Paul MSP Delta
Nashville BNA Southwest
New Haven HVN Avelo · seasonal
New York (LaGuardia) LGA Delta
Newark EWR Allegiant, United
Orlando (International) MCO Allegiant, Southwest
Orlando (Sanford) SFB Allegiant
Philadelphia PHL American, Allegiant
Phoenix (Sky Harbor) PHX Allegiant · seasonal
Punta Gorda/Fort Myers PGD Allegiant
Sarasota/Bradenton SRQ Allegiant
St. Petersburg/Clearwater PIE Allegiant
Tampa TPA Southwest · seasonal
Washington (Dulles) IAD United, Allegiant
Washington (Reagan National) DCA American

Allegiant

destinations from TYS · 13 year-round · 8 seasonal

Knoxville's biggest network. TYS has been an Allegiant aircraft base since October 2018. Mostly leisure routes, a few days a week.

Southwest

destinations from TYS · 4 year-round · 3 seasonal · plus Las Vegas announced

New on March 5, 2026. Nashville twice daily, Baltimore, Dallas Love and Orlando daily, plus weekend seasonal routes.

American

destinations from TYS · 6 year-round · 0 seasonal

Hub flights to Charlotte, Chicago, Dallas/Fort Worth, Philadelphia, Miami and Reagan National.

United

destinations from TYS · 5 year-round · 0 seasonal

Chicago, Houston, Denver, Dulles and, since September 24, 2026, Newark twice daily.

Delta

destinations from TYS · 4 year-round · 0 seasonal

Atlanta, Knoxville's busiest route, plus Detroit, Minneapolis and LaGuardia.

Avelo

destination from TYS · 0 year-round · 1 seasonal

One route: New Haven, Connecticut, seasonal.

Side by side

Airlines compared

Airlines at Knoxville compared
Airline	Destinations	Year-round	Seasonal	Only airline on	Hubs reached from TYS	Connections on one ticket
Allegiant	21	13	8	BOS, MDW, VPS, FLL, GUF, HOU, JAX, EYW, LAS, MEM, SFB, PHX, PGD, SRQ, PIE	None	No, nonstop only
Southwest	7	4	3	BWI, DAL, BNA, TPA	BNA, BWI, DAL, MCO, DEN, AUS, TPA (Southwest connects at these)	Yes
American	6	6	0	CLT, DFW, MIA, DCA	CLT (185 onward) ORD (180 onward) DFW (251 onward) PHL (123 onward) MIA (164 onward) DCA (90 onward)	Yes
United	5	5	0	IAH	ORD (209 onward) IAH (181 onward) EWR (165 onward) IAD (130 onward) DEN (201 onward)	Yes
Delta	4	4	0	ATL, DTW, MSP, LGA	ATL (225 onward) DTW (119 onward) MSP (146 onward) LGA (78 onward)	Yes
Avelo	1	0	1	HVN	None	Not from TYS (one route)

"Onward" counts the nonstop destinations that airline flies from each hub, from the hub's published destination list (Wikipedia, October 19, 2026). Allegiant sells only point-to-point nonstop itineraries; Avelo flies one route from TYS.

Destinations from TYS

Who flies the most destinations

Allegiant21
Southwest7
American6
United5
Delta4
Avelo1

Midtown Atlanta's skyline silhouetted against a pink and violet sunset

DeltaAtlantaThe busiest TYS route.

Aerial view of Uptown Charlotte's skyline with Bank of America Stadium in the foreground

AmericanCharlotteAmerican's TYS hub route.

Chicago's skyline at sunset across the lakefront, led by the twin-antenna John Hancock Center

American and UnitedChicagoTwo airlines to O'Hare.

Nashville's skyline across the Cumberland River, with the twin-spired AT&T Building above the riverfront's historic brick buildings

SouthwestNashvilleTwice daily.

Request a nonstop

Where should Knoxville fly next?

Name the city. Every request is counted and the leaderboard goes to the airport's air-service team, the people who pitch new routes to airlines.

… requests from TYS so far

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Questions

What airlines fly out of Knoxville?

Six: Allegiant (21 destinations), Southwest (7 destinations), American (6 destinations), United (5 destinations), Delta (4 destinations), Avelo (1 destination), as of October 19, 2026.

Which airline has the most flights from Knoxville?

By destinations, Allegiant, with 21. By passengers on a single route, Delta to Atlanta is the busiest.

Does Southwest fly to Knoxville?

Yes, since March 5, 2026. See Southwest at Knoxville.

Does Frontier fly to Knoxville?

Not anymore. Frontier ended its only TYS route, Denver, on August 17, 2026.

Does Delta fly nonstop from Knoxville?

Yes: Atlanta, Detroit, Minneapolis-St. Paul and New York LaGuardia.

Sources